Publications

• Heifets BD, Olson DE. Therapeutic mechanisms for psychedelics and entactogens. Neuropsychopharmacology. 2024 Jan;49(1):104-118. 

• Lii TR, Smith AE, Flohr JR, Okada RL, Nyongesa CA, Cianfichi LJ, Hack LM, Schatzberg AF, Heifets BD. Randomized Trial of ketamine masked by surgical anesthesia in depressed patients. Nat Mental Health 2023 Oct 19;1:876-886.  
• Hack LA, Zhang X, Heifets BD, Suppes T, van Roessel P, Yesavage JA, Rodriguez CI, Deisseroth CI, Knutson B, Williams LM. Ketamine’s acute effects on negative brain states are mediated through specific altered states of dissociation and consciousness in human subjects. Nat Commun. 2023 Oct 19;14(1):6631. 
• Bombardieri AM, Heifets BD, Treggiari M, Albers GW, Steinberg GK, Heit JJ. Cervical sympathectomy to treat cerebral vasospasm: a scoping review. Reg Anesth Pain Med. 2023 Oct;48(10:513-519). 
• Barbosa DAN, Gattas S, Salgado JS, Kuijper FM, Wang AR, Huang Y, Kakusa B, Leuze C, Luczak A, Rapp P, Malenka RC, Hermes D, Miller KJ, Heifets BD, Bohon C, McNab JA, Halpern CH. An orexigenic subnetwork within the human hippocampus. Nature 2023 Sep;621(7978): 381-388. 
• Hietamies TM, McInnes LA, Klise AJ, Worley MJ, Qian JJ, Williams LM, Heifets BD*, Levine SP*. The effects of ketamine on symptoms of depression and anxiety in real-world care settings: a retrospective controlled analysis. J Affect Disord 2023 Aug 15;335:484-492. (*co-senior authors). 
• Ruiz Colon GD, Ohkuma R, Pendharkar AV, Heifets BD, Li G, Lu A, Gephart MH, Ratliff JK. A protocol for reducing intensive care utilization after craniotomy: a 3-year assessment. Neurosurgery. 2023 May1;92(5):1080-1090. 
• Rijsketic DR, Casey AB, Barbosa DAN, Zhang X, Hietamies TM, Ramirez-Ovalle G, Pomrenze M, Williams LM, Malenka RC, Heifets BD. UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice. (In press Neuropsychopharmacology. 2023 May 29. doi: 10.1038/s41386-023-01613-4. Biorxiv, posted Feb 21, 2023.

• Pomrenze MB, Cardozo Pinto DF, Neumann PA, Llorach P, Tucciarone JM, Morishita W, Eshel N, Heifets BD, Malenka RC. Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. Neuron. 2022 Dec 21; 110, 1-19.
• Reese MA, Heifets BD, Berger M. Intraoperative anesthetic probes of brain health: Ketamine as a canary in the coalmine? Anesthesia & Analgesia. 2022 Oct 1;135(4)679-682
• Chow HS, Hack LM, Kawai M, Heifets BD. Anesthetic-induced intra-operative dream associated with remission of a psychiatric disorder: a case report. A A Pract. 2022 Aug 10; 16(8)e01613.
• *Aday JS, *Heifets BD, Pratscher SD, Bradley E, Rosen R, Woolley JD. Great Expectations: Recommendations for improving the methodological rigor of psychedelic trials. Psychopharmacology. 2022 Jun;239(6):1989-2010. (*Contributed equally)
• McInnes LA, Qian JJ, Gargeya RS, DeBattista C, Heifets BD. A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings. J Affect Disord. 2022 Jan 6:S0165-0327(21)0141-2.
• Wu H, Kakusa B, Neuner S, Christoffel DJ, Heifets BD, Malenka RC, Halpern CH. Local accumbens in vivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2109269118.

• Wu X, Morishita W, Beier KT, Heifets BD, Malenka RC. 5-HT modulation of a medial septal circuit tunes social memory stability. Nature. 2021 Nov;599(7883):96-101
• Hack LM, Warthen KG, Zhang X, Heifets BD, Suppes T, van Roessel P, Rodriguez CI, Knutson B, Williams LM. Acute ketamine modulated functional brain coupling and dissociative and affective states in human subjects: interim analyses. Biorxiv, posted Sept 23 2021.
• Walsh JJ, Llorach P, Cardozo Pinto DF, Wenderski W, Christoffel DJ, Salgado JS, Heifets BD, Crabtree GR, Malenka RC. Systemic enhancement of serotonin signaling reverses social deficits in multiple models for ASD. Neuropsychopharmacology. 2021 Jul 8. Online ahead of print
• Christoffel DJ, Walsh JJ, Hoerbelt P, Heifets BD, Llorach P, Lopez RC, Ramakrishnan C, Deisseroth K, Malenka RC. Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2106648118
• Heifets BD, Bentzley BS, Williams N, Schatzberg AF. Unraveling the opioid actions of S-ketamine and R-ketamine: comment on Bonaventura et al. Mol Psychiatry. 2021 May 18. Online ahead of print
• Christoffel DJ, Walsh JJ, Heifets BD, Hoerbelt P, Neuner S, Sun G, Ravikumar VK, Wu H, Halpern CH, Malenka RC. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nat Commun. 2021 Apr 9;12(1):2135
• Heifets BD, Malenka RC. Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics. Neuropsychopharmacology. 2021 Jan;46(1):261
• De Gregorio D, Aguilar-Valles A, Preller KH, Heifets BD, Hibicke M, Mitchell J, Gobbi G. Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine.  J Neurosci. 2021. Feb 3;41(5):891-900

• Heifets, B. D. Piercing the ketamine cloud. Anesthesiology. 2020
• Heifets, B. D., Malenka, R. C. Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2020
• Steinberg, E. E., Gore, F., Heifets, B. D., Taylor, M. D., Norville, Z. C., Beier, K. T., Földy, C., Lerner, T. N., Luo, L., Deisseroth, K., Malenka, R. C. Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning. Neuron. 2020; 106(6):1026-1043

• Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., Walsh, J. J., Sze, J. Y., Malenka, R. C. Distinct neural mechanisms for the prosocial and rewarding properties of MDMA. Science translational medicine. 2019; 11 (522)
• Williams, N. R., Heifets, B. D., Bentzley, B. S., Blasey, C., Sudheimer, K. D., Hawkins, J., Lyons, D. M., Schatzberg, A. F. Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism. Molecular psychiatry. 2019; 24(12):1779-1786
• Cayla, N. S., Dagne, B. A., Wu, Y., Lu, Y., Rodriguez, L., Davies, D. L., Gross, E. R., Heifets, B. D., Davies, M. F., MacIver, M. B., Bertaccini, E. J. A newly developed anesthetic based on a unique chemical core. Proceedings of the National Academy of Sciences of the United States of America. 2019; 116(31):15706-15715
• Heifets, B. D., Malenka, R. C. Disruptive Psychopharmacology. JAMA psychiatry. 2019
• Heifets, B. D., Williams, N. R., Bentzley, B. S., Schatzberg, A. F. Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine’s Antidepressant Effect. JAMA psychiatry. 2019; 76(6):657-58
• Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., Schatzberg, A. F. Rigorous Translational Models Are Key to Studying Ketamine’s Antidepressant Mechanism: Response to Wang and Kaplin. The American journal of psychiatry. 2019; 176 (5): 412
• Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., Schatzberg, A. F. Interpreting Ketamine’s Opioid Receptor Dependent Effect: Response to Sanacora. The American journal of psychiatry. 2019; 176 (3): 249–50
• Heifets, B. D., Williams, N. R., Blasey, C., Sudheimer, K., Rodriguez, C. I., Schatzberg, A. F. Target Population, Dose, and Timing Considerations for Understanding Naltrexone’s Subjective Effect: Response to Amiaz. The American journal of psychiatry. 2019; 176 (3): 251–52

• Williams, N. R., Heifets, B. D., Blasey, C., Sudheimer, K., Pannu, J., Pankow, H., Hawkins, J., Birnbaum, J., Lyons, D. M., Rodriguez, C. I., Schatzberg, A. F. Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism. The American journal of psychiatry. 2018; 175(12):1205-1215
• Walsh, J. J., Christoffel, D. J., Heifets, B. D., Ben-Dor, G. A., Selimbeyoglu, A., Hung, L. W., Deisseroth, K., Malenka, R. C. 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature. 2018;560(7720):589-594
• Heifets, B. D., Tanaka, P., Burbridge, M. A. Fluid management concepts for severe neurological illness: an overview. Current opinion in anaesthesiology. 2018;31(5):526-531
• Heifets, B. D., Crawford, E., Jackson, E., Brodt, J., Jaffe, R. A., Burbridge, M. A. Case Report of an Awake Craniotomy in a Patient With Eisenmenger Syndrome. A&A practice. 2018; 10 (9): 219–22
• Hoerbelt, P., Heifets, B. D. Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms. Methods in enzymology. 2018; 602: 301–38

2017

• Beier, K. T., Kim, C. K., Hoerbelt, P., Hung, L. W., Heifets, B. D., DeLoach, K. E., Mosca, T. J., Neuner, S., Deisseroth, K., Luo, L., Malenka, R. C. Rabies screen reveals GPe control of cocaine-triggered plasticity. Nature. 2017; 549(7672):345-350

2016

• Heifets, B. D., Malenka, R. C. MDMA as a Probe and Treatment for Social Behaviors. Cell. 2016; 166 (2): 269–72

2014

• Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., Malenka, R. C. Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science. 2014; 345 (6196): 535-542
• Nie, J., Sharma, B., Maclver, B., Heifets, B. D. HIPPOCAMPAL GABAERGIC FIELD POTENTIALS: A NOVEL HIGH THROUGHPUT SCREEN FOR GENERAL ANESTHETICS IN RAT. LIPPINCOTT WILLIAMS & WILKINS. 2014: S144

2013

• Heifets, B. D., Deisseroth, K., Malenka, R., MacIver, B. IMPROVING DEEP BRAIN STIMULATION THROUGH TARGETED SYNAPTIC MODIFICATION. LIPPINCOTT WILLIAMS & WILKINS.2013: 159
• Heifets, B. D., Smith, S. M., Leong, M.S. Acute Cardiovascular Toxicity of Low-Dose Intrathecal Ziconotide. Pain medicine (Malden, Mass.). 2013

2009

• Heifets, B. D., Castillo, P. E. Endocannabinoid Signaling and Long-Term Synaptic Plasticity. ANNUAL REVIEW OF PHYSIOLOGY. 2009; 71: 283-306

2008

• Heifets, B. D., Chevaleyre, V., Castillo, P. E. Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008; 105 (29): 10250-10255

2007

• Chevaleyre, V., Heifets, B. D., Kaeser, P. S., Sudhof, T. C., Purpura, D. P., Castillo, P. E. Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1 alpha. NEURON. 2007; 54 (5): 801-812

2002

• Gold, S. J., Heifets, B. D., Pudiak, C. M., Potts, B. W., Nestler, E. J. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. JOURNAL OF NEUROCHEMISTRY. 2002; 82 (4): 828-838
• Woodruff-Pak, D. S., Green, J. T., Pak, J. T., Heifets, B., Pak, M. H. The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure. INTEGRATIVE PHYSIOLOGICAL AND BEHAVIORAL SCIENCE. 2002; 37 (2): 103-113
• Pak, J., Green, J., Heifets, B., Pak, M., Woodruff-Pak, D. Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit. Medical science monitor. 2002; 8 (4): BR105-12

2000

• Baggott, M., Heifets, B., Jones, R. T., Mendelson, J., Sferios, E., Zehnder, J. Chemical analysis of ecstasy pills. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 2000; 284 (17): 2190-2190

1999

• Witkin, J. M., Gasior, M., Heifets, B., Tortella, F. C. Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1999; 289 (2): 703-711